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GERD pathogenesis, pathophysiology, and clinical manifestations

Zhao, R

When to decrease dose Consider decreasing if: Persistent side effects that don't resolve Excellent results achieved and maintenance desired Budget constraints require conservation Stacking and wanting to optimize ratios Many researchers find they can reduce dose during maintenance phases after achieving initial goals during more intensive loading phases

Specifically, reduced GLP-1 was associated with altered expression of the pro-inflammatory macrophage marker CD86

Dosedependent efficacy: Higher doses (2.44.5 mg) demonstrate greater weight loss than lower doses (0.31.2 mg) [4]